Iontophoresis as an important method of producing physiologic phenomena and of introducing chemical substances into the body was first utilized by Leduc.1 This investigator pointed out that bodily phenomena were in essence electrical and that iontophoresis was a means of introducing ions into the organism and modifying the prevailing ionic relationship. This paper is the classic start of a long series of investigations. No attempt will be made in this paper to review the literature.
In respect to ophthalmology, Wirtz2 developed a technic by which the galvanic current was used to introduce chemical substances into the eye and thus to treat various diseases of the eye. He made no study of the influence of iontophoresis on intraocular pressure, nor did he use sodium chloride, which is the basis for the work here reported.
Cantonnet3 used drugs by means of the galvanic current in the form of iontophoresis
THAU W, MYERSON A. EFFECT OF IONTOPHORESIS ON THE EYEWITH SPECIAL REFERENCE TO INTRAOCULAR TENSION. Arch Ophthalmol. 1940;24(4):761–764. doi:10.1001/archopht.1940.00870040147012