Interstitial keratitis is a well known cause of impaired vision or blindness. Its importance may be seen from a previous study by the Cooperative Clinical Group,1 which showed that interstitial keratitis is the most frequent disabling complication of congenital syphilis. This complication was found in approximately one third of 1,010 cases studied.
—The present study comprises an analysis of the records of 532 patients with interstitial keratitis who were treated or observed for at least one year. All of the patients had congenital syphilis. Although other aspects of interstitial keratitis were considered, the study was particularly concerned with the evaluation of various methods of antisyphilitic treatment in terms of the visual acuity of the patient at final examination.2Visual acuity was determined for some patients with refraction and for other patients without refraction. It is apparent from chart 1 (particularly with regard to patients
KLAUDER JV, VANDOREN E. INTERSTITIAL KERATITISANALYSIS OF FIVE HUNDRED AND THIRTY-TWO CASES WITH PARTICULAR REFERENCE TO STANDARDIZATION OF TREATMENT. Arch Ophthalmol. 1941;26(3):408–429. doi:10.1001/archopht.1941.00870150082005