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Article
April 1942

THE CORNEAII. TRANSFER OF WATER AND SODIUM CHLORIDE BY HYDROSTATIC PRESSURE THROUGH THE EXCISED CORNEA

Author Affiliations

BOSTON
From the Harvard Medical School and the Howe Laboratory of Ophthalmology.

Arch Ophthalmol. 1942;27(4):696-704. doi:10.1001/archopht.1942.00880040072006
Abstract

The potential forces affecting the transfer of water and dissolved substances through the cornea are osmosis, diffusion and hydrostatic pressure. It is the purpose of this and the preceding paper1 of this series to report the effect of these forces on the excised cornea. While the experimental results should not be unqualifiedly applied to the conditions in vivo, it is our belief that the different factors can be separately evaluated only in the relatively simple in vitro preparations. Previously we have reported the effect of diffusion and that special instance of diffusion, osmosis, for the transfer of water and sodium chloride through the excised cornea.

Our objectives in the present study are threefold : (1) to compare the amounts of fluid transferred by a given hydrostatic pressure through the cornea before and after removal of its constituent membranes; (2) to compare the amount of fluid transferred through the intact cornea,

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