The therapeutic value of sulfanilamide and its derivatives is now an established fact. The brilliant clinical results obtained by oral and intravenous administration of these drugs prompted this investigation as to their value when used locally in the treatment of ocular diseases. Kolmer1 pointed out the efficacy of sulfanilamide crystals (applied locally) in the prevention and the treatment of infections of superficial wounds. Recently Luo and P'an2 demonstrated that the concentration of sulfanilamide in the aqueous humor is considerably greater after local use of powdered sulfanilamide than after oral administration of large doses of the drug or after local use of the drug in liquid form.
Azosulfamide was the first member of the drug group used by us locally in the eye. It was first available in a 2.5 per cent solution and was instilled into the eye in the treatment of various kinds of acute conjunctivitis and
CONNELL ES, TROWBRIDGE BC. LOCAL USE OF SULFANILAMIDE AND DERIVATIVES IN PRACTICE OF OPHTHALMOLOGY. Arch Ophthalmol. 1942;27(4):705–706. doi:10.1001/archopht.1942.00880040081007