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Article
June 1945

INFLUENCE OF LOCAL APPLICATION OF SULFONAMIDE COMPOUNDS AND THEIR VEHICLES ON REGENERATION OF CORNEAL EPITHELIUM

Author Affiliations

PHILADELPHIA
From the Department of Ophthalmology of the University of Pennsylvania.

Arch Ophthalmol. 1945;33(6):463-467. doi:10.1001/archopht.1945.00890180059005
Abstract

There have appeared excellent reviews by Bellows,1 Alvaro,2 Thygeson3 and Wagener4 concerning the toxic properties of the sulfonamide compounds on ocular structures. Although much has been written about the toxic influence of these compounds on wound healing elsewhere in the body, only recently has consideration been given to their influence on healing of ocular wounds. Bellows considered this property in his review in June 1943. The data for these conclusions were based on the experimental work of Bellows and Gluckman.5 These authors concluded that locally applied sulfonamide compounds greatly deter regeneration of corneal epithelium. Berens, De Gara and Loutfallah6 demonstrated in 1943 that the average healing time of the wounds of the cornea treated with sulfonamide ointment or with the ointment base alone was usually greater than the average healing time of the untreated eyes. They suggested that the local use of the sulfonamide

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