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Article
November 1946

DIISOPROPYL FLUOROPHOSPHATE ("DFP") IN TREATMENT OF GLAUCOMA

Arch Ophthalmol. 1946;36(5):621-622. doi:10.1001/archopht.1946.00890210631009

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Abstract

To the Editor:  —The advent of diisopropyl fluorophosphate ("DFP") in ophthalmology probably marks a significant advance in the medical control of glaucoma. The disconcerting ciliary spasm and after-blur, however, will limit its field to cases of glaucoma inadequately controlled by the previously known antiglaucomatous drugs, as intimated by Leopold and Comroe in their introductory article (Use of Diisopropyl Fluorophosphate in the Treatment of Glaucoma, Arch. Ophth.36: 1 [July] 1946.About five months ago Dr. Leopold graciously sent me a generous supply of "DFP," which my associates and I have been using in selected cases at Cook County Hospital and at the Veterans Administration Facility, Hines, Ill., as well as in private practice. The optimum results have generally been obtained with a 0.05 per cent solution administered morning and evening. Stronger solutions cause more discomfort, and in cases in which the 0.05 per cent concentration has failed to lower the

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