THE OCCURRENCE of cataract following the ingestion of dinitrophenol was first reported in 1935.1 Within the next six years 177 cases had been published in the literature.2
Thorough experimentation on laboratory animals prior to the release of dinitrophenol for medical use was carried out by Tainter and his fellow workers at Stanford University School of Medicine. Further careful work was done following the report of cataracts due to dinitrophenol in man. In no instance was it possible to produce cataracts in the ordinary laboratory animals,3 nor was it possible to produce experimental cataracts by feeding dinitrophenol to animals deficient in vitamins A, B or C.4 The incidence of cataracts could not be increased when dinitrophenol was administered in conjunction with such cataractproducing agents as lactose and galactose.5 The animals used in all instances were mammals.
Until recently it was assumed that cataracts did not develop
BETTMAN JW. PRODUCTION OF CATARACTS IN CHICKS WITH DINITROPHENOL. Arch Ophthalmol. 1946;36(6):674-676. doi:10.1001/archopht.1946.00890210685002