CYCLOPS is a fetal monstrosity with a single central eye. Some reports of this interesting anomaly have been made, but relatively few have included detailed studies of the eyes. Because of the interesting anomalies observed in 2 cases of cyclops, this report has been prepared. The bibliography was recently reviewed by Krafka1 and Kindred,2 and an extensive study was made by Adelmann.3 This malformation was described in the mythology of the ancient Greeks in a race of giants called cyclopes. They were destroyed by Apollo, who was angry at them for forging the thunderbolt that killed his son Aesculapius, the great physician.
Cyclopia is a congenital anomaly but is not hereditary, since life is impossible; in the usual case the child is born dead or dies soon after birth, so that no cyclops has ever reproduced. A familial incidence has not been reported, except by Klopstock.4
GARTNER S. CYCLOPIA. Arch Ophthalmol. 1947;37(2):220-231. doi:10.1001/archopht.1947.00890220229014