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Article
July 1947

PATHOLOGIC STUDY OF OCULAR LESIONS DUE TO LEWISITE (β-CHLOROVINYLDICHLOROARSINE)Changes With and Without BAL (2,3-Dimercaptopropanol) Therapy

Author Affiliations

PHILADELPHIA
From the Department of Ophthalmology of the University of Pennsylvania Hospital.

Arch Ophthalmol. 1947;38(1):89-108. doi:10.1001/archopht.1947.00900010092006
Abstract

IN STUDYING the pathologic changes produced by various war. gases, it became apparent that certain histologic events were common to all. All eyes exposed to severe burns with mustard gas (2-chloroethyl sulfide),1 lewisite (β-chlorovinyldichloroarsine)2 and nitrogen mustards (β-chloroethylamine)3 showed the following alterations:

  1. Epithelial changes, followed by loss of epithelium

  2. Endothelial changes, followed by loss of endothelium

  3. Alteration of stromal cells, leading to death of the cell, disappearance of stromal nuclei and, eventually, some loss of stromal substance

  4. Edema of the corneal stroma

  5. Cellular infiltration of the cornea first with polymorphonuclear leukocytes and later with lymphocytes and large mononuclear cells

  6. Vascularization of the cornea

  7. Changes in the iris and ciliary body, consisting chiefly of congestion, cellular infiltration and dispersion of pigment

  8. Alteration of the anterior chamber, consisting of deposition of serum and fibrin and cellular infiltration

  9. Lenticular changes, ranging from vacolation to permanent opacification

  10. Reparative processes, consisting of newly formed capillaries and fibroblastic tissue

  11. Evidences of secondary infection

These histologic events

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