OCULAR involvement and cataractous changes in the lens have been reported under a great number of experimental conditions (tetany; diabetes, including galactose and xylose cataract; thallium intoxication; riboflavin deficiency) and clinically in association with various cutaneous diseases, as well as with mongolism and myotonia.1
More recently, blindness with opacities of the lens was described by Curtis and associates,2 and cataractous changes in the lens with vascularization of the cornea were reported by Totter and Day,3 Albanese and Buschke4 and Buschke5 in rats on tryptophan-deficient diets.
During the past four years we have been studying the effects of various amino acid-deficient diets on the growth, development, morphology of various body tissues and organs, endocrine glands and nervous system in rats. Up to the present we have observed ocular involvement with diets deficient in tryptophan and valine.
In rats on a tryptophan-deficient diet we were able to
FERRARO A, ROIZIN L. OCULAR INVOLVEMENT IN RATS ON DIETS DEFICIENT IN AMINO ACIDSI. Tryptophan. Arch Ophthalmol. 1947;38(3):331-341. doi:10.1001/archopht.1947.00900010340005