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October 1947


Author Affiliations

Consultant in Ophthalmology, United States Veterans Administration WASHINGTON, D. C.; NEW YORK
From the Eye, Ear, Nose and Throat Service of the Veterans Administration Hospital, Washington, D. C.

Arch Ophthalmol. 1947;38(4):461-467. doi:10.1001/archopht.1947.00900010474004

LINDAU'S disease is an angiomatosis of the central nervous system characterized by the occurrence of single or multiple hemangioblastomas in the cerebellum, brain stem or spinal cord, associated with angiomatosis of the retina (von Hippel's disease). In addition, there are present various congenital lesions of other organs, such as cystic disease of the kidneys and pancreas. Lindau found that the retinal lesions made their appearance at the average age of 25, while cerebellar symptoms did not become manifest until about fourteen years later, when partial blindness had usually set in. Cox and Trumble1 pointed out that autopsy of patients with this disease has frequently revealed a hemangioma of the spinal cord which clinically had shown no evidence of its presence. The case to be described is unique in that compression of the cord by a vascular tumor was the primary and outstanding feature and only later was a typical,

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