In the summer of 1946 my colleagues and I experienced considerable trouble with infections due to Bacillus pyocyaneus (Pseudomonas aeruginosa) as secondary contaminations with our surgical dressings. Although we tried many preparations and various procedures to control the contamination, none proved particularly successful. We finally had a case in which an infection with B. pyocyaneus invaded the inside of the eye after an operation for cataract and the eye was lost.
About this time we heard of "sulfamylon"1 (para-[aminoethyl]benzene sulfonamide hydrochloride), which was said to be suitable for ophthalmic use. The preparation was available in both 1 and 4 per cent solutions, buffered with citrate to a pH of 6.5.
"Sulfamylon" is a sulfonamide compound with a wide range of antibacterial activity, but, unlike most of these drugs, it is not inhibited by paraaminobenzoic acid. It has, therefore, proved effective in the presence of pus and blood. For
CLARK WB. LOCAL USE OF "SULFAMYLON" (PARA-[AMINOETHYL]-BENZENE SULFONAMIDE HYDROCHLORIDE). Arch Ophthalmol. 1947;38(5):682-683. doi:10.1001/archopht.1947.00900010699011