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Article
December 1947

CORNEAL AND CONJUNCTIVAL PIGMENTATION AMONG WORKERS IN HYDROQUINONE

Author Affiliations

Boston.
Howe Laboratory of Ophthalmology, 243 Charles Street.

Arch Ophthalmol. 1947;38(6):847. doi:10.1001/archopht.1947.00900010870012
Abstract

To the Editors:  —In connection with Dr. Banks Anderson's article, entitled "Corneal and Conjunctival Pigmentation Among Workers Engaged in the Manufacture of Hydroquinone," which appears in this issue of the Archives, it may be of interest to note our unsuccessful attempts in the Howe Laboratory to produce pigmentation of the cornea and conjunctiva in rabbits and guinea pigs by acute exposure to parabenzoquinone vapor. This is the compound presumably responsible for the pigmentation in human beings. Three albino rabbits and 6 guinea pigs were introduced into an exposure chamber containing solid quinone spread out on a tray, but separated from contact with the animals. The concentrations of parabenzoquinone vapor in the chamber at various times were as low as 2 parts, and as high as 13 parts, per million. The concentration in the plants where Anderson's patients worked varied between 0.01 and 3.2 p.p.m.1The animals were examined after

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