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Article
February 1948

DEGENERATION AND REGENERATION OF NERVES IN CORNEAL TRANSPLANTATIONAn Experimental Study

Arch Ophthalmol. 1948;39(2):135-161. doi:10.1001/archopht.1948.00900020140001
Abstract

LITTLE work has been done on the degenerative and regenerative nerve changes that occur in the corneal transplant. It has even been thought that reinnervation of the graft has to do with its transparency or opacification.

In 1915 and 1917, Leoz1 undertook experimental work to study the regeneration of nerves in the corneal transplant. At that time, the technic of corneal transplantation had not yet reached its present development and high percentage of success. Leoz worked mostly with partial and complete circular keratotomies, and the few homotransplants made were rather large, 9 mm. in diameter, and circular, and the graft was fastened to the host cornea with interrupted sutures. Only 1 of his rabbits with homotransplants had a partially clear graft; this rabbit was killed eight months after the operation, and a study of its nerves was made. He stated that sixty days after the operation he obtained an

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