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Article
March 1948

EXPERIMENTAL STUDIES OF OCULAR TUBERCULOSISIX. Failure of Penicillin to Affect the Course of Experimental Ocular Tuberculosis

Author Affiliations

BALTIMORE
From the Wilmer Ophthalmological Institute and the Department of Pathology of the Johns Hopkins Hospital and University.

Arch Ophthalmol. 1948;39(3):261-266. doi:10.1001/archopht.1948.00900020268001
Abstract

THERE is little in the literature concerning the effect of penicillin on Mycobacterium tuberculosis. Abraham, Chain and Florey,1 as a result of their in vitro experiments, reported the tubercle bacillus to be insensitive to penicillin. In Woodruff and Foster's experiment,2 tubercle bacilli (type and virulence unstated) were not inhibited by 1,000 units of penicillin per cubic centimeter of culture medium. They attributed the insensitivity of the tubercle bacillus to the fact that it is among the most active destroyers of penicillin. Smith and Emmart3 found that neither a concentration of 3,000 units of penicillin per hundred cubic centimeters of culture medium prevented growth of a virulent human type of bacillus in vitro nor did 800 units of penicillin affect significantly the degree of tubercle development in the chorioallantoic membrane. Gerber and Gross4 reported that a concentration of 1,500 units per cubic centimeter of culture medium did

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