ACCIDENTAL ocular infection with vaccinia occurs usually as a complication of prophylactic immunization against smallpox. Rarely infection results from a laboratory accident during the preparation or experimental use of the virus. The danger of ocular infection lies in involvement of the cornea, with subsequent development of an opaque scar.
The prevention of permanent impairment of vision is a goal in treating any infection of the eye. The therapy of ocular vaccinia is not standardized. Various forms of radiation therapy have been used in human beings and in rabbits. The present experiments were suggested by the beneficial results obtained from the use of roentgen therapy for an accidental ocular infection in a partially immune human being.1
Rabbits were used to study the effect of direct irradiation at different stages of ocular vaccinia in nonimmune and partially immune animals and the nonspecific effect of irradiation of a distant primary
HARRELL GT, REID CH, LITTLE JM, MANKIN JW, PITTMAN HW, HOLT LB, MORRIS LM. EFFECT OF ROENTGEN THERAPY ON EXPERIMENTAL OCULAR VACCINIA IN NONIMMUNE AND IN PARTIALLY IMMUNE RABBITS. Arch Ophthalmol. 1948;39(3):313-324. doi:10.1001/archopht.1948.00900020320006