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Article
June 1948

CONTROVERSIAL POINTS IN PENICILLIN THERAPY OF OCULAR DISEASES

Author Affiliations

With the Technical Assistance of Miss Jeanette Di Grandi, B.A. NEW YORK
From the Department of Ophthalmology of Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Ophthalmol. 1948;39(6):752-804. doi:10.1001/archopht.1948.00900020762004
Abstract

OUTLINE OF STUDY 

  • Parenteral use of penicillin

    1. Passage of penicillin across blood-aqueous barrier

    2. Penicillin level in ocular and other body fluids after ligation of renal vessels

    3. Passage of penicillin from blood into aqueous and vitreous in ocular inflammation

  • Surface applications of penicillin

    1. Solutions and ointments

    2. Iontophoretic introduction of penicillin

      1. Conductivity of sodium penicillin

      2. Influence of change in hydrogen ion concentration at cathode on activity of penicillin

      3. Factors acting on passage of penicillin through cornea during iontophoresis

        • Flow of electric current from cathode

        • Changes in hydrogen ion concentration of bathing fluid

        • Polarity of terminal

        • Tonicity of penicillin solution

    3. Value of high drug levels in aqueous after corneal iontophoresis or similar procedures

    4. Palpebral iontophoresis

  • Local injections of penicillin

    1. Under conjunctiva

    2. Into anterior chamber

    3. Into lens

    4. Into vitreous

      1. Crystalline penicillin

      2. Penicillin and antitoxin

  • General conclusions

The literature on the use of penicillin in ophthalmology has grown extensively in the last few years

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