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July 1948

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSISXI. Effect of "Promin" and "Promizole" in Experimental Ocular Tuberculosis in the Normal Rabbit

Author Affiliations

From the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University.

Arch Ophthalmol. 1948;40(1):1-13. doi:10.1001/archopht.1948.00900030004001

IN A PREVIOUS paper,1 the effect of treatment with two sulfone compounds, "promin" (the sodium salt of p, p'-diaminodiphenylsulfone-N,N'-didextrose sulfonate) and "promizole" (4,2-diaminophenyl-5'thiazoylsulfone), on experimental ocular tuberculosis in the immuneallergic rabbit was reported. It was found that both these drugs exerted a strongly deterrent action on the course of the ocular tuberculosis. This deterrent action became evident after the third week of treatment. While histologic evidences of tuberculosis persisted in the healed eyes, the lesions were much fewer and less severe than in the control eyes. In transmission experiments, in which tissue from the eyes of treated rabbits was inoculated into normal rabbits, only one eye of the treated animals was found to be infectious.

These experiments were performed on immune-allergic rabbits—animals with a preexisting systemic tuberculosis at the time the eyes were inoculated. As a result of the systemic infection, these rabbits had a well developed acquired

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