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Article
July 1948

EXPERIMENTAL INVESTIGATION OF THE PATHOGENICITY OF DIPHTHEROIDS ISOLATED FROM THE HUMAN CONJUNCTIVA

Author Affiliations

PHILADELPHIA; SAN FRANCISCO
From the Laboratory for Ophthalmic Research, Mount Zion Hospital, San Francisco; the Department of Pathology, University of California School of Medicine, and the Laboratories of the Jewish Hospital, Philadelphia.

Arch Ophthalmol. 1948;40(1):23-38. doi:10.1001/archopht.1948.00900030026003
Abstract

GENERAL CONSIDERATIONS 

Bacteriologic Features of Diphtheroids.  —The first attempt to establish an etiologic relation between a diphtheroid and a disease of the eye dates back to 1879, when Italian investigators1 isolated Corynebacterium xerose during the course of an institutional epidemic of xerophthalmia. Later, in 1883, German workers demonstrated the presence of diphtheroids on the conjuctiva of patients with a nutritional deficiency. However, it was soon realized that these bacteria are usually present on normal and inflamed conjunctivas, as well as on other normal and diseased surfaces of the body. It is of interest to note that in a recent review of the subject, published by the British Medical Research Council, the statement was made2:It is very doubtful if C. xerose is even now sufficiently well characterized to deserve a specific rank. So authors present a picture formed from composite conceptions of various workers.Likewise, the report of

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