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September 1948


Author Affiliations

From the Departments of Ophthalmology and Medicine of Grady Hospital and Emory University School of Medicine, and the Georgia Department of Public Health.

Arch Ophthalmol. 1948;40(3):302-310. doi:10.1001/archopht.1948.00900030308008

Although penicillin has been extensively employed in the treatment of various syphilitic infections, only a few reports have been made evaluating its use in ocular syphilis.1 During the past three years we have used penicillin in the treatment of 39 patients with various manifestations of syphilis of the eye. The results are presented in this report.

INTERSTITIAL KERATITIS  The efficacy of any form of therapy for interstitial keratitis must be considered in the light of the natural course of this infection. Untreated syphilitic interstitial keratitis involves both eyes in the majority of cases.2 Involvement of the second eye may occur from weeks to years after that of the first and may lead to functional blindness (vision less than 20/200). The usefulness of one eye is lost in almost 20 per cent of untreated patients and that of both eyes in 6 per cent.2a According to Klauder and

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