IN 19311 I published the results of a microscopic study of the incidence of invasion of the optic nerve by retinoblastoma. The report was based on a series of 119 enucleated eyes containing retinoblastoma. In 53 per cent of the eyes the tumor had extended into the optic nerve beyond the lamina cribrosa. In 43 per cent of the eyes the optic nerve was not severed at operation beyond the tumor extension, and, therefore, residual tumor had been left in that portion of the nerve remaining in the orbit. Thus, in 43 per cent of the cases a recurrence in the orbit and fatal termination were to be expected unless measures were directed against the residual tumor left in the nerve at the time of operation. The globes from which these statistics were gleaned were enucleated between the years 1878 and 1929, a period of fifty-one years.
REESE AB. INVASION OF THE OPTIC NERVE BY RETINOBLASTOMA. Arch Ophthalmol. 1948;40(5):553-557. doi:10.1001/archopht.1948.00900030566007