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Article
December 1948

HYPERCALCEMIA AND BAND KERATOPATHYReport of Nineteen Cases

Author Affiliations

BOSTON
From the Howe Laboratory of Ophthalmology, Harvard Medical School; the Eye Service of the Massachusetts Eye and Ear Infirmary; the Department of Medicine of Harvard Medical School, and the Medical Service of the Massachusetts General Hospital.

Arch Ophthalmol. 1948;40(6):624-638. doi:10.1001/archopht.1948.00900030639004
Abstract

ABNORMALITIES in serum calcium values have only recently been recognized to have ocular manifestations. The first reported observation is that of Meesmann (1938).1 In his study on hypocalcemia Meesmann included a case in which band-shaped opacities of the cornea and opacities of the conjunctiva developed while the blood calcium was high. The cause of the hypercalcemia was overdosage with AT 10® (dihydrotachysterol), which the patient had been taking for hypoparathyroidism following thyroidectomy. The patient also had glaucoma, and Meesmann stated the belief that the primary cause of the opacities was glaucomatous dystrophy of Bowman's membrane, but he suggested that the hypercalcemia might have been a contributing cause and pointed out significantly that the opacities became less as the blood calcium was reduced to normal. Haldimann (1941)2 described band-shaped opacities of the cornea in 2 patients with sarcoid and hypercalcemia. In view of the fact that the opacities developed

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