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Article
March 1949

INHERITANCE OF ARACHNODACTYLY, ECTOPIA LENTIS AND OTHER CONGENITAL ANOMALIES (MARFAN'S SYNDROME) IN THE E. FAMILY

Author Affiliations

PHILADELPHIA; ANN ARBOR, MICH.
From the Departments of Surgery and Medicine, the University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

Arch Ophthalmol. 1949;41(3):276-305. doi:10.1001/archopht.1949.00900040284002
Abstract

MARFAN'S disease is a syndrome which in its fullest expression is characterized by an elongate, slender body build, especially evident in the extremities; skeletal deformities (kyphosis, scoliosis, pigeon breasts, pes planus, hammer toes); dolichocephalic skull; poorly developed and hypotonic musculature; laxity of the joints and ligaments; scanty subcutaneous fat; malformation of the ears; malformations of the lungs; congenital heart disease and ocular anomalies, especially ectopia lentis. There is great variability in the degree to which these traits are expressed. The numerous publications which have appeared since the condition was first described by Marfan1 in 1896, have been reviewed by Weve,2 Burch,3 Marfan,4 Futcher and Southworth,5 Clement6 and Rados,7 to whose papers the reader is referred for a complete bibliography and discussion of the syndrome. The articles by Lloyd8 stimulated interest in the syndrome among American ophthalmologists. The present communication will describe an

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