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Article
April 1949

VASCULARIZATION OF THE CORNEAIts Experimental Induction by Small Lesions and a New Theory of Its Pathogenesis

Author Affiliations

BOSTON
From the Howe Laboratory of Ophthalmology, Harvard Medical School, and Massachusetts Eye and Ear Infirmary.

Arch Ophthalmol. 1949;41(4):406-416. doi:10.1001/archopht.1949.00900040416002
Abstract

THE STUDY of new blood vessel formation has attracted many investigators. In recent times the process has been studied at some length in cold-blooded animals (Krogh1) by observation through a transparent integument and in some warm-blooded animals by means of glass chambers inserted in the ears (Sandison,2 Clark and Clark and associates3). The cornea has also served for the study of new vessel formation, both in human beings (Augstein,4 Brückner,5 Koeppe,6 Kreiker7) and in animals. Of the latter, the most noteworthy studies are those of Ehlers,8 emphasizing the morphology of the vessels in the cornea, and of Julianelle and Lamb,9 Julianelle and Bishop10 and Swindle,11 emphasizing the sequence of events which take place during the formation of new vessels.

The cornea has obvious advantages for the study of new vessel formation, since it is a relatively homogeneous tissue and

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