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Article
May 1949

HISTOPATHOLOGIC ASPECTS OF RETROLENTAL FIBROPLASIA

Author Affiliations

CHICAGO
From the Department of Ophthalmology, Northwestern University Medical School.

Arch Ophthalmol. 1949;41(5):553-561. doi:10.1001/archopht.1949.00900040569002
Abstract

MUCH has been accomplished by various authors (Reese,1 Krause,2 Ingalls,3 Owens4) in clarifying the confusion of multiple terms and descriptions of apparently related conditions since Terry5 first drew attention to a disturbance connected with prematurity to which he applied the not very appropriate, but in ophthalmologic circles now almost generally accepted, term of retrolental fibroplasia.

The pathogenesis of retrolental fibroplasia and of the conditions apt to be confused with it is of two principal, and essentially unrelated, varieties.

The first type, apparently not connected with maternal-fetal infection or premature birth, is characterized by arrest of embryonic growth, with or without aberrant growth of the involved tissues. There is commonly a familial or hereditary background, and more often than not the condition is unilateral. These genetically predetermined maldevelopments may have their inception at any period of gestation and range from complete failure of primary retinal coaptation

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