[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.144.194.161. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 1949

PRODUCTION OF CATARACT IN RATS BY BETATETRALOL AND OTHER DERIVATIVES OF NAPHTHALENE

Author Affiliations

WASHINGTON, D. C.; BALTIMORE
From the Division of Pharmacology, Food and Drug Administration, Federal Security Agency, Washington, D. C., and the Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine.

Arch Ophthalmol. 1949;41(5):572-582. doi:10.1001/archopht.1949.00900040588005
Abstract

SINCE Bouchard's1 discovery in 1886 that naphthalene produced cataract in rabbits, a large number of experimental papers have been published on the subject. Relatively few authors, however, have attempted to approach the mechanism of this production of cataract by studying the cataractogenic properties of chemically related substances. Kolinski2 failed to produce cataract with nitronaphthalene, β-naphthol and anthracene. Salffner3 had negative results with 1,5-dioxynaphthalene, 2,3-dioxynaphthalene and 2,7-dioxynaphthalene. He found the cataractogenic properties of naphthalene greatly enhanced by phthalic acid; however, control experiments with other agents which likewise produced renal damage led him to conclude that the effect was a result of damage to the kidney, producing a delayed excretion of naphthalene or a toxic derivative. Igersheimer and Ruben4 reported negative results with both a- and β-naphthol, while van der Hoeve5 produced cataracts in rabbits with β-naphthol. Jess6 observed occasional fine reversible clefts and opacities in

First Page Preview View Large
First page PDF preview
First page PDF preview
×