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Article
October 1949

PENETRATION OF AUREOMYCIN INTO THE EYE

Author Affiliations

NEW YORK
From the Department of Opthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Ophthalmol. 1949;42(4):365-372. doi:10.1001/archopht.1949.00900050373002
Abstract

THE EFFECTIVE use of aureomycin in treatment of several external infections of the eye has been reported by Braley.1 Because of the possibility that aureomycin may be of value also for intraocular infections, the current study was undertaken to determine the penetration of this new antibiotic into rabbit eyes following various methods of administration.

TECHNIC 

Topical Application.  —The technic as described by von Sallmann2 was used in iontophoresis, the corneal bath and subconjunctival injection. A fresh solution of 0.5 per cent aureomycin borate was made daily, distilled water being used as the solvent. After production of local anesthesia with 6 drops of 0.1 per cent dibucaine hydrochloride (nupercaine hydrochloride®), the applicator tube was filled to the halfway mark (2.5 to 3.0 cc. of solution). At the end of the procedure the excess fluid was carefully removed, and about 0.25 cc. of aqueous was withdrawn at stated intervals

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