THE SUBJECT of this investigation was the histologic changes produced in the retina of experimental animals by anemia. Several methods of causing anemia were used.
Soon after the advent of the ophthalmoscope in ophthalmology, in 1851, changes occurring in the retina from anemic states initiated much speculation. It was in 1895 that von Graefe1 described the first case of embolism of the central retinal artery. In 1890 Wagenmann2 contributed his extensive studies on vascular lesions affecting the eye in rabbits. The central retinal artery was sectioned behind the globe, and histopathologic studies were made after various periods. He also severed the posterior ciliary vessels behind the globe and studied sections after various periods. He concluded that section of the optic nerve and central vessels did not cause retinal edema but that this change followed section of the ciliary arteries only. Holden,3 in 1899, performed bleeding experiments on
TURNBULL W. EFFECTS OF EXPERIMENTAL RETINAL ANEMIA IN RATS. Arch Ophthalmol. 1950;43(1):9-31. doi:10.1001/archopht.1950.00910010012002