WHEN INVOLVEMENT of the mucous membrane accompanies erythema multiforme bullosum, serious ocular sequelae may occur. Of 162 previously reported cases of erythema multiforme with mucosal involvement, the eyes were affected in 148. The ocular picture varied from mild mucopurulent conjunctivitis to perforating corneal ulcers destroying the globe. The striking increase in the number of cases reported recently and the high percentage with ocular lesions make it important for the ophthalmologist to be aware of the ocular implications of erythema multiforme.
Unfortunately, the literature has been cluttered with many cumbersome names for mucosal involvement accompanying erythema multiforme of the skin. A brief survey of titles used is presented in an attempt to clarify the current nomenclature.In 1866 Hebra1 proposed the name "erythema exudativum multiforme" for a cutaneous disease identified by variously shaped erythematous lesions of the skin. He cited a rare variant of erythema multiforme with accompanying severe
PATZ A. OCULAR INVOLVEMENT IN ERYTHEMA MULTIFORME. Arch Ophthalmol. 1950;43(2):244-256. doi:10.1001/archopht.1950.00910010251007