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Article
March 1950

USE OF PARAAMINOSALICYLIC ACID ALONE OR IN ASSOCIATION WITH STREPTOMYCIN IN OCULAR TUBERCULOSISExperimental and Clinical Investigations

Author Affiliations

Professor of Ophthalmology, University of Pavia PAVIA, ITALY

Arch Ophthalmol. 1950;43(3):431-445. doi:10.1001/archopht.1950.00910010440003
Abstract

OF THE substances recently proposed for the chemotherapy of of tuberculosis, only sulfones and streptomycin have received attention from ophthalmologists, while information is still lacking on the most recent discovery in this field, paraaminosalicylic acid, already recognized as valuable in treatment of extraocular tuberculosis. The Tb 1/698 of Domagk (a thiosemicarbazone preparation) and the "asiaticoside" (derived by Boiteau from the plant Hydrocotyle asiatica) are still awaiting a more complete trial of their antituberculosis properties.1

It would take too much space to report here what has already been done with sulfones and streptomycin in experimental ocular tuberculosis, and it seems hardly necessary to recall the outstanding contributions published in the United States by Steenken and his associates, and in particular by Alan Woods and his collaborators.

They proved that sulfones (promin® [N, N′-didextrose sulfonate, the sodium salt of P,P′-diaminodiphenyl sulfone]) and promizole® [4,2′-diaminophenyl-5′-thiazolylsulfone] ) exert a definite deterrent action

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