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March 1950

DIBUTOLINE SULFATEComparative Clinical Study of Cycloplegic Effects

Author Affiliations

Chief, Refraction Department, Wills Hospital PHILADELPHIA
From the Refraction Department of the Wills Hospital.

Arch Ophthalmol. 1950;43(3):446-453. doi:10.1001/archopht.1950.00910010455004

IN 1944 Swan and White1 found that certain derivatives of a number of choline esters, rather than possessing a parasympathomimetic action comparable to other choline esters, competed physiologically with the acetylcholine normally present in the body and thus behaved as parasympatholytic drugs. The most promising member of this group appeared to be dibutylcarbamate of dimethylethyl-2-hydroxyethyl ammonium sulfate, which was given the name dibutoline sulfate.

PHARMACOLOGY  Dibutoline sulfate (dibutylcarbamate of dimethylethyl-2-hydroxyethyl ammonium sulfate) is chemically related to carbachol U. S. P. (carbamylcholine chloride; doryl®) but possesses different physical properties and has antagonistic pharmacologic effects on the intraocular muscles. For example, dibutoline is surface active and mydriatic; carbachol is surface inactive and miotic.Dibutoline produces paresis of smooth muscles innervated by the parasympathetic nervous system. Its effect on the smooth muscles, therefore, simulates that of paralysis of the oculomotor nerve, that is,

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