THE OCCURRENCE of scotoma in the central visual fields during or after streptomycin therapy is presented in 11 cases. In 10 of these cases the patient was being treated for pulmonary tuberculosis, and in 1, for an infection of the urinary bladder with Escherichia coli. In a twelfth case, that of a man who had been treated for pulmonary tuberculosis, there was no field defect. These 12 patients, who had received the full course of streptomycin therapy, represent all persons whose visual fields it was possible to determine.
The only previously reported case of a visual field defect occurring in conjunction with streptomycin therapy is that of Schultz1; in this case there was an altitudinal hemianopsia, with subsequent full recovery.
The field defects in the cases reported were of the nerve fiber bundle type and represent a form not previously reported with this therapy.2 I have not found
THOMAS EB. SCOTOMAS IN CONJUNCTION WITH STREPTOMYCIN THERAPYReport of Eleven Cases. Arch Ophthalmol. 1950;43(4):729-741. doi:10.1001/archopht.1950.00910010742011