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Article
April 1950

OCULAR LESIONS INDUCED BY ACUTE EXPOSURE OF THE WHOLE BODY OF NEWBORN MICE TO ROENTGEN RADIATION

Author Affiliations

BETHESDA, MD.

Arch Ophthalmol. 1950;43(4):742-749. doi:10.1001/archopht.1950.00910010755012
Abstract

MUCH HAS been written concerning cataract formation in experimental animals and in man following local roentgen and radium irradiation of the eye. The literature on this subject was exhaustively reviewed by Desjardins1 in 1931 and by Warren2 in 1943. Since most of the experimental work was published in the early part of the century, many of the data given on dosage and other conditions of irradiation cannot be reliably interpreted in terms of present standards. Nevertheless, the following effects were clearly established: 1. Irradiation often produces an irreversible opacity of the lens. 2. The lens is considerably more radiosensitive in immature, rapidly growing animals than in mature animals. 3. In immature animals irradiation frequently affects not only the lens but also the retina, while in mature animals only the lens is affected. In 1942 Poppe3 described experiments in which the eyes of adult rabbits were exposed to

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