FAMILY groups have been reported1 in whose members ptosis of the eyelids appeared at birth as a mendelian dominant trait. The present report is concerned with a family group in which ptosis developed in certain members, also as a mendelian dominant trait, only after the eyelids had been normal until 40 years of age.
The earliest known affected member (1, fig. 1) was born in the 1840's, had normal eyelids within the memory of some living members of the family and first noted drooping of the lids at about the age of 40, the ptosis increasing in degree until his death, at the age of 70, when he was virtually blind. It is stated that he could lift his lids only a mere bit. Four of his 7 children had ptosis of the eyelids in later life.
Member 15, a granddaughter of 1, was 68 years of age. In
CAMERON PB. FAMILIAL PTOSIS OF THE EYELIDS APPEARING IN MIDDLE LIFE. Arch Ophthalmol. 1950;43(5):818-822. doi:10.1001/archopht.1950.00910010833004