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May 1950

STUDIES IN EXPERIMENTAL OCULAR TUBERCULOSISXIII. Effect of Streptomycin and Promizole® in Experimental Ocular Tuberculosis in the Normal Rabbit

Author Affiliations

From the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University.

Arch Ophthalmol. 1950;43(5):834-844. doi:10.1001/archopht.1950.00910010849006

IN A PREVIOUS report,1 it was shown that a combination of streptomycin and promizole® (4, 2′-diaminophenyl-5′-thiazolylsulfone) had a marked therapeutic effect on experimental ocular tuberculosis in immune-allergic rabbits. It is well known that experimental ocular tuberculosis runs a much severer and more fulminating course in the normal rabbit than it does in the previously infected, or immuneallergic rabbit. The following experimental studies were therefore undertaken to determine (1) the effect of streptomycin and promizole® on experimental ocular tuberculosis in the normal rabbit—a much severer test of the therapeutic efficacy of these agents—and (2) whether these agents operated independent of the immunity factor produced by a former systemic infection.

PLAN OF EXPERIMENT  Thirty normal rabbits, of both sexes, and of the same stock used in the previous experiments of this series, were inoculated in the anterior chamber of the right eye with 0.1 cc. of a six week culture

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