IT HAS recently been shown by one of us1 that the parasympathomimetic activity consistently demonstrable in the aqueous of nonglaucomatous eyes is either absent or diminished in eyes with chronic simple glaucoma. In the presentation of that work, it was suggested that this parasympathomimetic deficiency might be due either to an actual decrease in the normal acetylcholine content of the aqueous or to an inhibition or counteraction of its effect by other substances. It occurred to us that strong sympathetic stimulation of the eye, by producing an excess of sympathomimetic substance in the aqueous, might cause such a condition. This idea suggested the possibility that chronic simple glaucoma might be associated with ocular adrenergic hyperactivity and, consequently, that therapeutic effects might be produced in that disease through the use of a sufficiently potent sympatholytic drug.
In 1926 Thiel2 used ergotamine in the treatment of chronic simple glaucoma and
BLOOMFIELD S, HAIMOVICI H. EFFECT OF DIBENAMINE® IN CHRONIC SIMPLE GLAUCOMA. Arch Ophthalmol. 1950;43(6):969-978. doi:10.1001/archopht.1950.00910010986002