BECAUSE of recent advances in the knowledge of the functional importance of cholinesterase, it was considered advisable to investigate this enzyme from the ophthalmologic point of view. The purpose of this paper is to review the literature and to present new experimental data on the activity of cholinesterase in various ocular tissues and fluids, both in the experimental animal and in man.
I. REVIEW OF THE LITERATURE
A. GENERAL LITERATURE
Since Loewi's1 fundamental discovery in 1921 of a parasympathomimetic substance in the perfusion fluid passed through a dog's heart, literally thousands of papers have been published pertaining to this parasympathomimetic substance—acetylcholine—and its specific enzyme, cholinesterase. The existence of such an enzyme was first demonstrated by Loewi and Navratil,2 and the Stedmans,3 in 1932, gave it the present name of cholinesterase. The most important chemical and physiologic characteristics of cholinesterase have been well summarized in several review articles
deROETTH A. CHOLINESTERASE ACTIVITY IN OCULAR TISSUES AND FLUIDS. Arch Ophthalmol. 1950;43(6):1004-1025. doi:10.1001/archopht.1950.00910011021005