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This 600 page volume, apparently the first of a series, can conveniently be divided into two sections. The first deals chiefly with the physiologic effects of adrenocorticotropic hormone (ACTH), as exhibited by normal persons and as studied in patients treated for various diseases. It mentions the effect of ACTH on the total eosinophil count and the total lymphocyte count; its effect on elevated blood pressure; its effect on protein and carbohydrate metabolism and its effect on electrolytes, namely, retention of sodium and chlorides and fluids with reduced serum potassium levels.
The second part deals with the effects of ACTH on certain specific diseases. These include rheumatoid arthritis, gout, rheumatic fever, lupus erythematosus, myasthenia gravis, nephritis, nephrosis, spontaneous hypoglycemia, allergic states, lymphomas, periarteritis nodosa and ulcerative colitis, which seem to be at least temporarily benefited. Conditions such as tuberculosis, cancer, dermatomyositis, poliomyelitis scleroderma and schizophrenia seem to be very little affected.
Proceedings of the First Clinical ACTH Conference.. Arch Ophthalmol. 1950;43(6):1135. doi:10.1001/archopht.1950.00910011152020