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Article
November 1950

METABOLISM OF THE STORED CORNEA

Author Affiliations

NEW YORK
From the department of Ophthalmology, Columbia University College of Physicians and Surgeons.

AMA Arch Ophthalmol. 1950;44(5):659-665. doi:10.1001/archopht.1950.00910020671004
Abstract

SINCE preservation of the donor material is one of the most important problems facing the ophthalmologist who is actively engaged in doing corneal transplantations, several investigators1 have studied the question from the clinical, histological and biochemical points of view. In a recent article, Duane2 demonstrated that the oxygen uptake of the cornea remains normal for about seven days when the eye is stored in a moist chamber in the refrigerator. Preliminary experiments3 conducted in this laboratory showed that when the enucleated eyeball is stored in a moist chamber in the refrigerator, the procedure employed by Duane,2 and also the method employed nowadays in most of the eye banks in this country, the cornea rapidly takes up water. Of course, the abnormal hydration will change the corneal architecture and will cause histological and biochemical changes. It is obvious that the excessive water which diffuses into the cornea

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