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March 1951


Author Affiliations

From the Department of Ophthalmology, Hospital of the University of Pennsylvania, the University of Pennsylvania School of Medicine and the Children's Hospital.

AMA Arch Ophthalmol. 1951;45(3):301-316. doi:10.1001/archopht.1951.01700010307005

THE PURPOSE of this paper is to present preliminary clinical observations on the use of ACTH and cortisone when administered systemically and locally in the treatment of a variety of ocular lesions. The more important facts concerning the physiological effects of these hormones, beneficial and otherwise, which are essential for their clinical use are briefly reviewed. Excellent surveys of existing knowledge concerning their complex metabolic and therapeutic effects have been made available by Hench and associates,1 Sprague and associates,2 Mote3 and the Proceedings of the Staff Meetings of the Mayo Clinic since April 1949. Some knowledge of the action of these potent hormones is important in helping to choose ocular conditions which might benefit from such therapy and likewise in recognizing and preventing toxic or otherwise undesirable manifestations.

HISTORICAL SURVEY  In 1849 Addison demonstrated that the adrenal cortex was essential for life and showed that there was

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