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March 1951


Author Affiliations

From The Howe Laboratory, Massachusetts Eye and Ear Infirmary.

AMA Arch Ophthalmol. 1951;45(3):317-319. doi:10.1001/archopht.1951.01700010323006

CORTISONE has been used as local medication in certain ophthalmic diseases at the Massachusetts Eye and Ear Infirmary during the past six months. The purpose of this report is to record the observations and results of our experience with a series of 53 patients.

There are numerous reports in the literature of the effectiveness of intramuscular injections of pituitary adrenocorticotropic hormone (ACTH) and cortisone in treatment of diseases of the eye. There are also reports of hazards and contraindications to the systemic use of these new drugs. Thus, Thorn and associates1 have stated:

ACTH is contraindicated in diabetes mellitus, congestive heart failure, hypertensive cardiovascular disease, Cushing's syndrome, acne, hirsutism, osteoporosis and osteomalacia. The same limitation is true of cortisone, with the exception of hypertensive cardiovascular disease.

Other disadvantages of the systemic use of these drugs are the expense, due to the large quantity required, and the necessity of hospitalizing the patient during the course of

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