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Article
June 1951

RATE OF TURNOVER OF ASCORBIC ACID IN AQUEOUS HUMOR IN RABBITS

Author Affiliations

BALTIMORE; UPPSALA, SWEDEN
From the Wilmer Ophthalmological Institute, Johns Hopkins Hospital (Dr. Becker), and the Pharmacological Institute, University of Uppsala (Drs. Linner and Barany).

AMA Arch Ophthalmol. 1951;45(6):653-656. doi:10.1001/archopht.1951.01700010668006
Abstract

THE RATE of turnover of ascorbic acid in the aqueous humor has been determined by two independent methods. Friedenwald and collaborators1 injected large amounts of ascorbic acid into the anterior chamber and observed a rate of disappearance of 0.8 per cent per minute. However, this value was obtained under obviously unphysiological conditions. Kinsey and Barany2 used a different method, based on the rate of entrance of ascorbic acid into the aqueous at high plasma levels. Kinsey3 had observed that the concentration of ascorbic acid in the aqueous was nearly constant above a certain critical plasma level. The plasma level was accordingly raised quickly above this critical concentration and kept there for a period of hours. The concentration of ascorbic acid in the aqueous in these circumstances rose and approached a ceiling of about 50 mg. per 100 cc. asymptotically with a rate constant of 1 per cent

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