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Article
September 1951

RATE OF FLOW OF AQUEOUS HUMOR IN NORMAL AND SCORBUTIC GUINEA PIGS

Author Affiliations

UPPSALA, SWEDEN
From the Pharmacological Institute, University of Uppsala.

AMA Arch Ophthalmol. 1951;46(3):326-336. doi:10.1001/archopht.1951.01700020335009
Abstract

THE INTIMATE mechanism for the secretion of aqueous humor and the part played by ascorbic acid in this process are still unknown. Friedenwald and collaborators1 proposed a secretory mechanism in which ascorbic acid is thought to play an important part as a metabolic mediator in a "redox-pump" system. In support of this hypothesis, several interesting observations have been presented. Of these, two seem to have the most direct bearing on the question: In even moderate scurvy, there are already a marked slowing in the rate of transport of basic dyes from stroma to epithelium in the ciliary processes and, simultaneously, a pronounced reduction in the rate of refilling of the anterior chamber after partial evacuation. This was thought to indicate a reduction in the rate of secretion of aqueous. The fact that the intraocular pressure was not disturbed was explained by the assumption of a stabilizing mechanism. Both these

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