OCULAR invlovement in lymphomatous disease has been a sufficiently uncommon event to warrant isolated and collected case reports at various intervals in the ophthalmologic literature. Until recent years, the ocular manifestations were usually reported as ophthalmologic entities, and little attention was given to the occurrence of systemic disease, either prior to or following ocular involvement.
The opinion commonly expressed in the older ophthalmologic literature is that isolated ocular lymphoma generally is not followed by systemic involvement. This stands in conflict with the more recent concepts that appearance of a lymphoma anywhere in the body heralds eventual lymphomatous dissemination, though it be many years distant.
The problem of whether a simple ocular lymphoma should be considered as the first manifestation of a systemic disease has not been settled. Since the ophthalmologist rarely has the privilege of seeing the patient who suffers systemic involvement without recurrent ophthalmic disease, the question is one
FEINSTEIN AR, KRAUSE AC. OCULAR INVOLVEMENT IN LYMPHOMATOUS DISEASE. AMA Arch Ophthalmol. 1952;48(3):328-337. doi:10.1001/archopht.1952.00920010336008