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Article
October 1952

REGRESSION OF METASTATIC LESIONS OF BREAST CARCINOMA FOLLOWING STERILIZATION

Author Affiliations

PHILADELPHIA
From the Department of Ophthalmology, Hospital of the University of Pennsylvania, the University of Pennsylvania School of Medicine, and the Children's Hospital.

AMA Arch Ophthalmol. 1952;48(4):455-459. doi:10.1001/archopht.1952.00920010464010
Abstract

THE PURPOSE of this paper is to report two cases of metastatic lesions from breast carcinoma which showed marked regression following sterilization by x-rays. Typical metastatic lesions in the choroid of both eyes in one case and lung metastases in both cases showed decided improvement after sterilization.

The prognosis for patients with carcinoma of the breast in whom metastases to distant structures, such as the lung or eye, have developed is considered hopeless. Radical excision of the primary tumor with or without local x-ray therapy may be indicated. This usually has no effect upon the metastases. Recent developments in therapy, however, have shown some promise in retarding the course of the disease. Among these measures for treating metastatic breast carcinoma are the use of hormones and castration. While the modes of action are unknown, it has been noted that alteration of the hormonal status of the patient by sterilization or

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