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Article
December 1952

PHENYLEPHRINE (NEO-SYNEPHRINE®) OINTMENTA Superior Preparation

Author Affiliations

DREXEL HILL, PA.
PHILADELPHIA

AMA Arch Ophthalmol. 1952;48(6):747-748. doi:10.1001/archopht.1952.00920010759011
Abstract

PHENYLEPHRINE (neo-synephrine®) hydrochloride was first described as a therapeutic agent in ophthalmology by Heath in 1936.1 The more recent literature has suggested additional uses for this drug.2 More widespread and frequent use of phenylephrine has been somewhat limited by the unsatisfactory preparations now on the market. All too frequently the ophthalmologist wishes to use the solution or emulsion, only to find that the contents of his bottle have turned a dirty brown. He also hears patients complain vigorously about the severe stinging that occurs, even though he has previously instilled a topical anesthetic.

NEW PREPARATION  To meet these objections, a preparation of 10% phenylephrine (neo-synephrine®) hydrochloride in a 0.75% methylcellulose base was made for one of us (J. W. D.).3 This drug comes in an ointment tube, is crystal clear, has a mildly gelatinous consistency, and comes out of the tube as a drop, rather than the

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