SEVEN cases of colloid degeneration of the retina recently observed in three generations of the same family are reported. The condition described is probably the same as the abiotrophy reported by Doyne as "honeycomb colloid choroiditis."1 Because none of the previous reports in the available literature concern American families, it seemed worth while to present the present review, together with a report of our cases.
The first reference in the literature to a familial occurrence of colloid degeneration of the retina was made in 1876 by Hutchinson,2 who observed that three of Warren Tay's original cases of "guttate choroiditis" were of siblings. It remained for Doyne,3 however, to describe the condition as a separate entity in 1899, when he observed the disease in four members of one family. In 1910 he reported an additional family of four, at which time Butler4 also reported a
ALPER MG, ALFANO JA. HONEYCOMB COLLOID DEGENERATION OF THE RETINA. AMA Arch Ophthalmol. 1953;49(4):392-399. doi:10.1001/archopht.1953.00920020402003