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April 1953


Author Affiliations

From the Department of Ophthalmology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, and the Children's Hospital of Philadelphia.

AMA Arch Ophthalmol. 1953;49(4):392-399. doi:10.1001/archopht.1953.00920020402003

SEVEN cases of colloid degeneration of the retina recently observed in three generations of the same family are reported. The condition described is probably the same as the abiotrophy reported by Doyne as "honeycomb colloid choroiditis."1 Because none of the previous reports in the available literature concern American families, it seemed worth while to present the present review, together with a report of our cases.

HISTORICAL REVIEW  The first reference in the literature to a familial occurrence of colloid degeneration of the retina was made in 1876 by Hutchinson,2 who observed that three of Warren Tay's original cases of "guttate choroiditis" were of siblings. It remained for Doyne,3 however, to describe the condition as a separate entity in 1899, when he observed the disease in four members of one family. In 1910 he reported an additional family of four, at which time Butler4 also reported a

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