HYDROCORTISONE acetate (Compound F)1 is similar in appearance to cortisone (Cortone) acetate; it is a milky suspension, and the vial must be well shaken before using. It is to be kept at room temperature.
Hydrocortisone, like cortisone, may be given subconjunctivally, or it may be used in the form of eye drops. However, it should not be given by mouth, nor should it be administered intramuscularly. By the two latter routes hydrocortisone has less than half the efficacy of cortisone; given subconjunctivally or in the form of eye drops, hydrocortisone is immeasurably superior to cortisone and, in fact, is efficacious where cortisone and corticotropin (ACTH) are both ineffective.
To make a 0.5% solution for use as eye drops, each cubic centimeter of the hydrocortisone is mixed in 3 cc. of suitable diluent.2 For subconjunctival injections, the hydrocortisone is used, directly from the vial, 0.5 cc. being given every
LAVAL J. USE OF HYDROCORTISONE (HYDROCORTONE) ACETATE IN OPHTHALMOLOGY. AMA Arch Ophthalmol. 1953;50(3):299-302. doi:10.1001/archopht.1953.00920030306006