IT HAS been our privilege to study two families certain members of which exhibited a rarely observed form of endothelial dystrophy of the cornea. A careful survey of the families revealed that the aberration is hereditary and most likely congenital. It is to be differentiated from the usually described endothelial dystrophy, or corneal guttata.
REVIEW OF LITERATURE
Polymorphous degeneration of the deep layers of the cornea is characterized by the presence of polymorphic opacities, vesicles, and concavities of the endothelium, and possibly Descemet's membrane.Koeppe1 (1916) was probably the first to describe this form of endothelial dystrophy. He presented six cases of his own in which keratitis bullosa interna was exhibited. This author postulated that the concavities were congenital pits on the inner corneal surface. In 1920 Koeppe reported 18 cases in which similar lesions were present. Since the eyes exhibited no other pathologic condition, the author concluded that
McGEE HB, FALLS HF. HEREDITARY POLYMORPHOUS DEEP DEGENERATION OF THE CORNEA. AMA Arch Ophthalmol. 1953;50(4):462-467. doi:10.1001/archopht.1953.00920030470006