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October 1953


Author Affiliations

From the Institute of Ophthalmology of the Presbyterian Hospital.

AMA Arch Ophthalmol. 1953;50(4):491-499. doi:10.1001/archopht.1953.00920030499010

THE BRILLIANT pioneering work of Friedenwald1 demonstrated that the aqueous humor of the eye is partly a secretion and that the active process responsible for this secretion is located mainly in the ciliary body. Some of the secretory glands in the body, such as the salivary glands, are known to respond when stimulated with certain autonomic drugs. Deutsch and Raper,2 and also Brock and associates,3 have reported that the submaxillary glands of cats showed an increased outpouring of saliva when the animals were given acetylcholine, physostigmine, pilocarpine, or epinephrine. This is paralleled in vitro by an increased oxygen uptake. Therefore they postulated a "stimulation metabolism," according to which the excitation of the salivary glands by the autonomic drugs would result in an increased oxidative metabolism concurrent with the increased flow of saliva. Since Friedenwald's experiments have shown that the ciliary body is a secretory organ, it was

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